Hericium erinaceus HE has been used for the treatment of digestive diseases for over years in China.
HE possesses many beneficial functions gyomorrák xenograft egér modellek as anticancer, antiulcer, antiinflammation and antimicrobial effects, immunomodulation and other activities. The aim of the studies was to evaluate the anticancer efficacy of two extracts HTJ5 and HTJ5A from the culture broth of HE against three gastrointestinal cancers such as liver, colorectal and gastric cancers in both of in vitro of cancer cell lines and in vivo of tumor xenografts and discover the active compounds.
Célzott terápiák Absztrakt A daganatok angiogenezistől nagymértékben függő gyomorrák ellenőrizetlen halált okoz, részben a kemorezisztencia miatt.
Tumor volumes and body weight were measured daily during the first 10 days and times a week thereafter to assess the tumor growth inhibition, tumor doubling time, partial and complete tumor response and toxicity.
They are more effective and less toxic compared to 5-FU in all four in vivo tumor models.
Gyomorrák, gyomor adenokarcinóma (ujmedicina, biologika)
However, further studies are required to find out the active chemical constituents and understand the mechanism of action associated with the super in vivo anticancer efficacy. In addition, future studies are needed to confirm our preliminary results of in vivo synergistic antitumor efficacy in animal models of tumor xenografts with the combination of HE extracts and clinical used anticancer drugs such as 5-FU, cisplatin and doxurubicin for the treatment of gastrointestinal cancers.
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Currently, there is no effective radiosensitizer in clinical use. Artemisinin and its derivates enhance radiotherapeutic effect in some kinds of tumors; however, whether artemisinin and its derivates can enhance the radiosensitivity of NSCLC remains unknown.
Therefore, in the present experiments, artemisinin and its derivatives were firstly screened for their radiosensitization on NSCLC A A cells and then the possible mechanisms were investigated. The results on the possible mechanisms showed artesunate increased the NO level within irradiated A cells. Therefore, artesunate should be further investigated as a radiosensitizer in clinical application.